Which is Better Omeprazole or Lansoprazole?

Omeprazole and Lansoprazole both belong to a group of medications known as proton pump inhibitors (PPI). They relieve acid influx by reducing the amount of acid produced in the stomach. This action promotes the healing of gastric and duodenal ulcers and other inflamed gastrointestinal tissue areas.

Both drugs are also prescribed for a number stomach acid-related conditions including Barrett’s Esophagus, GERD, Erosive Esophagitis, Duodenal Ulcer, Indigestion, Helicobacter Pylori Infection, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.


The Similarities and Differences Between Omeprazole and Lansoprazole

Both drugs belong to the same class of drugs, proton pump inhibitor (PPI). They belong to the same class means the mechanism of how they work is very similar. Drugs that are referred to as PPI inhibit the proton pump cells. These cells are found in the lining in the stomach and are responsible for producing the stomach acid.

Omeprazole contains 10 or 20 mg of Omeprazole as its active ingredient, while Lansoprazole may contain 15, 30 or 60 mg of Lansoprazole as its active ingredient. They, however, contain different inactive ingredients. Both drugs are available as tablets and capsules. Furthermore, they can be found as generic and branded drugs.

Omeprazole and Lansoprazole, which is Better?

Omeprazole and Lansoprazole belong to the same class of drugs and work similarly. Their method of use and conditions they are used to treat are also very similar. Both drugs are also approved by FDA. Over the years, they have undergone several clinical tests. So which of these PPI is better?

In 2000, Department of Medicine, and Health Services Research Center, Tucson VA Medical Center, Department of Medicine, Section of Gastroenterology, Syracuse VA Medical Center, Syracuse, New York, and Center of Ulcer Research and Education (CURE) carried out a clinical study on both drugs.

The conclusion of the clinical study was that patients who took Omeprazole 20 mg once daily tolerated the drug and felt almost effects as those who took Lansoprazole 30 mg twice daily in symptom control of patients with GERD.

The effects of Omeprazole and Lansoprazole have also been tested on patients of erosive esophagitis. According to a 2001 paper published by Jeffery D. Kim (MD), patients treated with Lansoprazole showed better symptoms of relief throughout the treatment.

The paper noted that on the first day of treatment, the Lansoprazole group was found to be 33% heartburn free, while the Omeprazole group were 25% heartburn free. Over the next three days, the figures were 56% and 49% respectively. This means that the effects of Omeprazole appear delayed. After 8 weeks of treatment, the report stated that the differences were very small.

In Conclusion

P.S All possible dosages and drug forms may not be included here. Before either is administered (especially for long-term prescriptions), doctors would consider your:

  • Age
  • Compatibility or reaction to the drugs
  • The condition being treated
  • The severity of your condition
  • Other medical conditions you have.

While Lansoprazole may seem to work better, doctors or pharmacist may sometimes prescribe Omeprazole. The main reason for this is either the patient reacts badly to the drug or has a condition that the active ingredient of Lansoprazole or Omeprazole would react with. So, before choosing either drug, please consult your physician.

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